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| Product Code | opr0034 |
|---|---|
| Uniprot ID | P00488 |
| Name | blood coagulation Factor XIII |
| Appearance | White lyophilized solid |
|---|---|
| Constituents | The rhFXIIIa is lyophilized from 20 mM tris-HCl pH 7.5, 150 mM NaCl, 1 mM EDTA, 1 mM DTT.Sample contains maltodextrin. |
| Storage | Store working aliquots at a minimum of -20°CAvoid repeated freezing and thawingDelivery at ambient temperature is possible |
| Description | Recombinant human Factor XIII is a homodimer (a2) composed of two chains held together by non covalent bonds. After activation of the zymogen by Thrombin and Ca2+ to its active form (a*2, Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is insoluble and resistant to lysis. |
| Produced in | Insect cells |
| Species | Human |
| Form | Recombinant |
| Gene ID | 2162 |
| Molecular weight | 83 kDaor 166 kDa |
| Principle | rhFXIIIa catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. |
| Purity | > 95% |
| Recommendations | Add the volume of water specified in the certificate of analysis under aliquotation to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots. For short term storage keep cooled on ice. |
| Product type | Proteins |
| Applications | Functional Assay |
| Research areas | Transglutaminase |
Plasmatic Transglutaminase 13 (FXIII) antibody
Plasmatic Transglutaminase 13 (FXIII) antibodyAvailable
Specific Plasmatic Transglutaminase (Factor XIII/ FXIII) Colorimetric Microassay Kit : FXIII-CovTest
A colorimetric microassay for quantification of Factor XIII activityAvailable
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covalab关于单克隆抗体
在免疫反应过程中，抗原加工细胞将静止的B细胞活化为浆细胞，以分泌针对该抗原的免疫球蛋白。从多个参与免疫反应的浆细胞克隆中，可以通过普通的细胞培养技术将每个分离。一旦分离，该细胞及其后代就会产生相同亚型的相同免疫球蛋白。这些免疫球蛋白于是被称为单克隆抗体，并且对所需抗原的一个表位具有相同的亲和力和特异性。
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